The occurrence rate of malignant tumors is high and the prognosis is unfavorable. As a new type of noninvasive treatment, ultrasonic cavitation has shown remarkable potential in the field of tumor treatment. This paper summarizes the principle and mechanism of ultrasonic cavitation, and discusses the application mode, therapeutic effect and influencing factors of ultrasonic cavitation in tumor treatment combined with clinical case analysis, so as to offer new ideas and methods for clinical tumor treatment.