Objective: To evaluate the diagnostic value of nomogram based on contrast-enhanced ultrasound (CEUS)in the differential diagnosis of intrahepatic cholangiocarcinoma (ICC) andSLI-RADS category M (LR-M) hepatocellular carcinoma (HCC), and to evaluate the diagnostic efficacy of the model. Methods: The contrast-enhanced ultrasound (CEUS) data of pathologically confirmed ICC and HCC patients were analyzed retrospectively. All the nodules were classified by CEUS LI-RADS. The propensity scores were matched according to the nodule size (ICC:LR-M class HCC=1:1). The patients were divided into the training set and the validation set according to 7:3. Using R software, the most characteristic CEUS signs of ICC were screened by Logistic analysis,and the nomogram model was constructed. The ROC curve, decision making and the calibration curve of the model was evaluated. Results: Compared with LR-M HCC, the most characteristic CEUS signs of ICC were circumferential enhancement in arterial phase, intra-tumoral vein, blurred boundary of unenhanced area, and unclear enhancement boundary of tumor. The nomogram model with CEUS features is constructed. The AUC of the ROC curve was 0.9062(training set) and 0.8908(validation set), and the model had good discrimination. The calibration curve showed that the prediction probability of the model was consistent with the actual pathological results. The clinical decision curve showed that the model was clinically significant. Conclusion: The nomogram based on the characteristics of CEUS was of high value in the differential diagnosis between ICC and LR-M HCC.