Objective To assess the role of increased ventricular-arterial stiffening on the left ventricular function in diabetes patients with preserved ejection fraction by ultrasound. Methods Seventy-nine diabetes patients and fifty-eight healthy subjects were enrolled as healthy control group. Arterial elastance(Ea),end-systolic elastance(Ees) and VAC were compared. Results The Ea of DM was higher than that of the controls(2.03±0.41 vs 1.86±0.62mmHg∕mL,P<0.05),which suggested arteries stiffness increased significantly. No significance of Ees was found between two groups(2.45±0.87 vs 2.40±1.04mmHg∕mL,P>0.05). VAC significantly increased than that of the controls(0.89±0.26 vs 0.81±0.17,P<0.05).Conclusions? Ultrasound provided a quantitatively and noninvasive method analyzing the state of ventricle-arterial system in diabetes patients.VAC in diabetes patients significantly differed from the controls.