Objective: To analyze the relationship between changes of ultrasound parameters and curative effect of conbercept in patients with branch retinal vein occlusion (BRVO) and macular edema (ME). Methods: A total of 62 patients with BRVO and ME in the hospital were enrolled between January 2021 and January 2024. According to random number table method, they were divided into photocoagulation group (31 cases, retinal laser photocoagulation) and conbercept group (31 cases, intravitreal injection of conbercept on basis of photocoagulation group). All patients underwent ultrasound examination before and after treatment. The clinical curative effect and adverse reactions, best corrected visual acuity (BCVA), central macular thickness (CMT), ultrasound parameters [peak systolic flow rate (PSV), end-diastolic flow rate (EDV), resistance index (RI)] of central retinal artery (CRA) and ocular artery (OA) were compared between the two groups before and after treatment. The relationship between BCVA, CMT and ultrasound parameters was analyzed by Pearson correlation analysis. Results: Compared to photocoagulation group after treatment, the indexes contained BCVA, PSV, EDV and RI of CRA in conbercept group were higher, on the direct opposite, the CMT of the former was lower (P<0.05). The response rate of clinical treatment in conbercept group was higher than that in photocoagulation group (96.77% vs 80.65%, P<0.05). After treatment, the incidence of adverse reactions between conbercept group and photocoagulation group come out to be no difference (16.13% vs 29.03%, P>0.05). The results of Pearson correlation analysis showed that BCVA was positively correlated with PSV, EDV and RI of CRA, while CMT was negatively correlated with them (P<0.05). Conclusion: Intravitreal injection of conbercept combined with retinal laser photocoagulation has significant clinical curative effect in patients with BRVO and ME, and ultrasound parameters can better reflect the curative effect.