| 摘要: |
| 目的：分析超声参数变化与视网膜分支静脉阻塞(BRVO)合并黄斑水肿(ME)患者康柏西普治疗疗效的关系。方法：选取2021年1月-2024年1月在本院收治62例BRVO合并ME患者,根据随机数表法将其分为光凝组(31例)和康柏西普组(31例),其中,光凝组实施视网膜激光光凝治疗,康柏西普组在光凝组的基础上实施玻璃体腔注射康柏西普联合治疗。分别于患者治疗前后进行超声检查,比较两组临床疗效和不良反应情况,患者治疗前后的最佳矫正视力(BCVA)和黄斑中心凹视网膜厚度(CMT)水平,比较两组治疗前后视网膜中央总动脉(CRA)和眼动脉(OA)的超声参数[收缩期峰值流速(PSV)、舒张末期流速(EDV)、阻力指数(RI)]；采用Pearson相关性分析患者BCVA及CMT水平和超声参数之间的关系。结果：治疗后,康柏西普组BCVA水平高于光凝组,CMT水平低于光凝组,患者CRA的超声参数PSV、EDV、RI值均高于光凝组(P＜0.05)。康柏西普组临床治疗有效率为96.77%,高于光凝组的80.65%(P＜0.05)。治疗后,康柏西普组不良反应发生率为16.13%,与光凝组的29.03%比较无差异(P＞0.05)。Pearson相关性分析结果显示,患者BCVA水平和CRA的PSV、EDV、RI值均呈正相关,CMT水平和CRA的PSV、EDV、RI值均呈负相关(P＜0.05)。结论：经玻璃体腔注射康柏西普联合视网膜激光光凝治疗BRVO合并ME患者临床疗效显著,且超声参数能较好的反映治疗疗效。 |
| 关键词: 超声参数 视网膜分支静脉阻塞 黄斑水肿 康柏西普 |
| DOI： |
| 投稿时间：2024-08-07修订日期：2024-10-14 |
| 基金项目: |
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| Relationship between changes of ultrasound parameters and curative effect of conbercept in patients with BRVO and ME |
| liujuan |
| () |
| Abstract: |
| Objective: To analyze the relationship between changes of ultrasound parameters and curative effect of conbercept in patients with branch retinal vein occlusion (BRVO) and macular edema (ME). Methods: A total of 62 patients with BRVO and ME in the hospital were enrolled between January 2021 and January 2024. According to random number table method, they were divided into photocoagulation group (31 cases, retinal laser photocoagulation) and conbercept group (31 cases, intravitreal injection of conbercept on basis of photocoagulation group). All patients underwent ultrasound examination before and after treatment. The clinical curative effect and adverse reactions, best corrected visual acuity (BCVA), central macular thickness (CMT), ultrasound parameters [peak systolic flow rate (PSV), end-diastolic flow rate (EDV), resistance index (RI)] of central retinal artery (CRA) and ocular artery (OA) were compared between the two groups before and after treatment. The relationship between BCVA, CMT and ultrasound parameters was analyzed by Pearson correlation analysis. Results: Compared to photocoagulation group after treatment, the indexes contained BCVA, PSV, EDV and RI of CRA in conbercept group were higher, on the direct opposite, the CMT of the former was lower (P<0.05). The response rate of clinical treatment in conbercept group was higher than that in photocoagulation group (96.77% vs 80.65%, P<0.05). After treatment, the incidence of adverse reactions between conbercept group and photocoagulation group come out to be no difference (16.13% vs 29.03%, P>0.05). The results of Pearson correlation analysis showed that BCVA was positively correlated with PSV, EDV and RI of CRA, while CMT was negatively correlated with them (P<0.05). Conclusion: Intravitreal injection of conbercept combined with retinal laser photocoagulation has significant clinical curative effect in patients with BRVO and ME, and ultrasound parameters can better reflect the curative effect. |
| Key words: Ultrasound parameter Retinal branch vein occlusion Macular edema Conbercept |
