Non-invasive and high-efficiency disease treatment has become a research focus in nanomedicine, where cell membrane coating technology has been demonstrated to significantly enhance the overall performance of nanoparticle delivery systems. Traditional nanoparticle delivery systems modified with cell membranes not only effectively evade immune clearance but also prolong their circulation time in the bloodstream while achieving precise targeting of diseased regions. The integration of ultrasound with cell membrane coating technology and nanoparticle delivery systems can enhance local drug concentration and address the limitations of conventional ultrasound-controlled delivery systems. This review summarizes recent advances in ultrasound-mediated biomimetic membrane-basedivery systems for medical diagnosis and therapeutic applications, aiming to provide novel perspectives and inspiration for future nanomedicine research.