As a novel non-invasive treatment modality, sonodynamic therapy (SDT) utilizes low-intensity ultrasound（US）to trigger sonosensitizer to generate reactive oxygen species（ROS）, which induce cellular oxidative damage and death, and has remarkable advantages in tissue penetration and reduced side effects. However, efficient sonosensitizers are still scarce. Recently, piezoelectric semiconductor nanomaterials have garnered attention as new types of sonosensitizers. These piezoelectric nanomaterials leverage their unique piezoelectric effect to enhance the separation and migration of electron (e?)/hole (h+) pair under ultrasound stimulation, thereby catalyzing the redox reactions of substrates and effectively increasing ROS production. This process realizes the conversion of ultrasound-mechanical energy into chemical energy, a phenomenon known as sono-piezo dynamic therapy (SPDT). SPDT holds promising applications across various biomedical fields, including cancer treatment, bacterial resistance, and atherosclerosis.