甲状腺良恶性结节超声特征、相关危险因素分析及列线图预测模型构建研究
DOI:
CSTR:
作者:
作者单位:

海军军医大学第一附属医院长海医院,超声科

作者简介:

通讯作者:

中图分类号:

基金项目:


Study on ultrasound characteristics and related risk factors of benign and malignant thyroid nodules and construction of nomogram prediction model
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    【】目的 探讨甲状腺良恶性结节的超声特征及相关危险因素,并构建列线图预测模型。方法 选取2019年1月~2023年8月在我院经病理学检查确诊的70例甲状腺恶性结节患者作为恶性组、同期确诊的甲状腺良性结节患者90例作为良性组,对比两组患者的结节超声特征、甲状腺超声影像报告和数据系统(TI-RADS)分类、一般资料,并对具有统计学意义的指标绘制列线图,建立甲状腺结节超声良恶性诊断的预测模型。结果? 恶性组患者甲状腺结节的低回声占比、微钙化灶检出率、纵横径之比≥1患者占比、晕环厚度≥2 mm患者占比、Adler分级≥2级患者占比均显著的高于良性组患者,差异均具有统计学意义(P<0.05);良性组和恶性组患者的结节形状、边缘特征、结节数量、结节后方回声衰减对比,差异均无统计学意义(P>0.05);恶性组患者甲状腺结节中TI-RADS分类为4类、5类及≥3类的患者占比显著的高于良性组患者,上述各项指标两组间对比差异具有显著性(P<0.05);Logistic回归模型,结果显示:甲状腺结节的低回声、纵横径之比≥1、晕环厚度≥2 mm、Adler分级≥2级、TI-RADS分类≥3类是甲状腺恶性结节的独立危险因素(P<0.05);列线图分析贡献最大的是TI-RADS分类、其次为结节的纵横径之比、晕环厚度、Adler分级、结节回声特征,列线图模型具有较好的判断价值(C指数=0.774,95%CI:0.628~0.811);以病理学结果作为金标准,TI-RADS分类鉴别诊断甲状腺结节良恶性的ROC曲线下面积AUC值为0.810,灵敏度为78.83%、特异度为80.64%;超声特征列线图模型鉴别诊断甲状腺结节良恶性的ROC曲线下面积AUC值为0.891,灵敏度为91.73%、特异度为84.33%,列线图的诊断效能更高。结论 根据甲状腺超声特征,按照TI-RADS分类、结节的纵横径之比、晕环厚度、Adler分级、结节回声特征建立列线图模型综合分析诊断甲状腺结节良恶性具有较高价值。

    Abstract:

    【】Objective?? Explore the ultrasound characteristics of thyroid tumors and the value of constructing a nomogram prediction model.?? Methods?? We selected 70 patients with thyroid malignant nodules confirmed by pathological examination in our hospital from January 2019 to June 2023 as the malignant group, and 90 patients with thyroid benign nodules confirmed at the same time as the benign group. We compared the ultrasound characteristics of the nodules, thyroid ultrasound imaging reports and data system (TI-RADS) classification, general information, and plotted column charts for statistically significant indicators between the two groups, Establish a predictive model for ultrasound diagnosis of benign and malignant thyroid nodules.?? Results?? The proportion of low echogenicity, microcalcification detection rate, aspect ratio≥1, halo thickness≥2 mm, Adler grade≥2, and posterior echo attenuation of thyroid nodules in malignant group patients were significantly higher than those in benign group patients, and the differences were statistically significant (P<0.05); There was no statistically significant difference in the shape, edge features, and number of nodules between the benign and malignant groups of patients (P>0.05); The proportion of patients with TI-RADS classification of 4, 5, and≥3 categories in thyroid nodules in the malignant group was significantly higher than that in the benign group, and the differences were statistically significant (P<0.05); The logistic regression model showed that hypoechogenicity, aspect ratio≥1, halo thickness≥2 mm, Adler grade≥2, and TI-RADS grade ≥3 were independent risk factors for thyroid malignant nodules (P<0.05); The TI-RADS classification has the greatest contribution in column chart analysis, followed by the aspect ratio of nodules, halo thickness, Adler grading, and nodule echo characteristics. The column chart model has good diagnostic value (C index=0.774, 95% CI: 0.628~0.811); Using pathological results as the gold standard, the AUC value under the ROC curve for TI-RADS classification and differential diagnosis of benign and malignant thyroid nodules is 0.810, with a sensitivity of 78.83% and a specificity of 80.64%; The AUC value of the ROC area under the curve for distinguishing benign and malignant thyroid nodules using the ultrasound characteristic column chart model is 0.891, with a sensitivity of 91.73% and a specificity of 84.33%. The diagnostic efficacy of the column chart is higher.Conclusion Establishing a line graph model based on thyroid ultrasound features, classified according to TI-RADS, followed by the ratio of longitudinal and transverse diameters of nodules, halo thickness, Adler grading, and nodule echo characteristics, has high value in the comprehensive analysis and diagnosis of benign and malignant thyroid nodules.

    参考文献
    相似文献
    引证文献
引用本文

彭欣雯,沈玥.甲状腺良恶性结节超声特征、相关危险因素分析及列线图预测模型构建研究[J].临床超声医学杂志,2025,27(3):

复制
相关视频

分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2024-08-27
  • 最后修改日期:2024-11-26
  • 录用日期:2024-12-02
  • 在线发布日期: 2025-04-02
  • 出版日期:
文章二维码

扫码关注

官方微信