In this article, we present a case of a 71-year-old female patient with stress cardiomyopathy with good clinical outcome who was followed up throughout the echocardiographic process. The combined use of two-dimensional speckle-tracking echocardiography as well as myocardial contrast echocardiography to obtain myocardial longitudinal and circumferential strain values of the left ventricle in the 18th segment and myocardial microcirculatory perfusion parameters quantitatively evaluated impaired left ventricular myocardial mechanics and myocardial microcirculatory disorders of the disease, and through the followup of this By following up the recovery of ventricular wall motion and myocardial perfusion, we found that there was a good negative correlation between the impaired left ventricular myocardial mechanics and reduced myocardial microcirculatory perfusion in this case, which further increased our understanding of this disease, and emphasized the necessity and importance of the joint use of the two new ultrasound techniques to follow up this disease, which provides an indispensable objective basis for guiding the clinical practice to make a definitive diagnosis, treat the patient in an early stage, and assess the efficacy of the treatment, as well as to improve the prognosis. This provides an indispensable objective basis for guiding clinical practice in clarifying diagnosis, early treatment, evaluating efficacy and improving prognosis.