摘要: |
目的 探讨缺乏心血管疾病临床表现的类风湿关节炎(rheumatoid arthritis, RA)活动期患者内皮功能的变化。方法 收集川北医学院附属医院风湿血液科检查并证实RA活动期住院患者45例,选取年龄、性别匹配的健康对照者45例,所有受试者均进行肱动脉超声检查,获取血管内膜-中层厚度(intima- media thickness, IMT)和血流动力学相关参数;同时测量右侧肱动脉内皮依赖性血管舒张功能(flow mediated dilation ,FMD)。 结果RA组肱动脉IMT、血流动力学参数(PSV、EDV)与对照组比较,差异不具有统计学意义(P>0.05);但是RA组FMD明显低于健康对照组(5.09±2.71% vs11.26±5.66%, P<0.001),差异具有统计学意义。 结论 缺乏心血管疾病临床表现的RA活动期患者在出现血管壁形态学改变及血流动力学异常之前,存在血管内皮功能的障碍。 |
关键词: 关节炎,类风湿 IMT FMD |
DOI: |
投稿时间:2017-03-12修订日期:2017-04-09 |
基金项目:四川省科技厅应用基础项目(2011JY0140) |
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Change in endothelium dependent vasodilation function in rheumatoid arthritis patients |
yangfang,yuewensheng |
(Affiliated Hospital of North Sichuan Medical College) |
Abstract: |
[ ] Objectives: To investigate the change in endothelium dependent vasodilation function in active rheumatoid arthritis(RA) patients without clinical manifestations of cardiovascular disease. Methods: Consecutive 45 active RA inpatients without clinical manifestations of cardiovascular disease and 45 age- and sex-matched healthy subjects were enrolled. Arterial intima media thickness(IMT),hemodynamic parameters of brachial arteries were tested by ultrasound ,in addition , Endothelial dependent flow - mediated dilation (FMD) of brachial artery was measured. Results: Compared with control groups, the IMT and hemodynamic parameters had no statistical significance in RA group(P>0.05),but FMD of brachial artery with rheumatoid arthritis were reduced(5.09±2.71% vs11.26±5.66%, P<0.001).Conclusions: Endothelial dysfunctionS occur in active RA patients without clinical manifestations of cardiovascular disease ,before morphological features of blood vessel walls and hemodynamics were changed. |
Key words: Arthritis ,Rheumatoid IMT FMD |