Objective To explore the correlation between lung ultrasonography and CT images in patients with COVID-19, and the role of lung ultrasound in evaluation of lesions in COVID-19 patients. Methods Doctors performed bedside lung sequential blind scan in 25 patients with COVID-19. The thickness, shape and integrity of pleural line, A line and the characteristics of B line, consolidation and pleural effusion were observed. Ultrasound semi-quantitative scoring procedures were performed and compared with chest CT images in the same period. SPSS24.0 statistical software was used to analyze the correlation between right, left, whole lung ultrasound score and the proportion of CT lesion volume. Compare the lung ultrasound score and the proportion of CT lesion volume of the general and severe(critical) group. Results The lowest total score of the whole lung was 0 (1 case) and the highest was 22 (1 case). There was significant difference in the total lung ultrasound scores of right lung and left lung (P<0.05)，as well as R1 to R6 areas and L1 to L6 areas (P<0.05). The correlation coefficients between the lung ultrasound scores of right, left, whole lung and the proportion of CT lesion volume were 0.942, 0.956 and 0.922, respectively（P<0.01）. The differences of lung ultrasound scores of general group [5 (4.25)] and severe(critical) group [14 (9.5)],the proportion of CT lesion volume of general group [4.3 (6.85)%] and severe(critical) group [22.4 (20.25) %] were statistically significant (both P<0.01). The lung ultrasound score in patients with COVID-19 is significantly correlated with the proportion of lesion volume in CT. Conclusion Compared with CT, bedside lung ultrasound plays an important role in non-invasive evaluation of pulmonary lesions in patients with COVID-19.