With the development of acoustic contrast agents, Contrast-enhanced ultrasound (CEUS) has significantly improved the accuracy of ultrasound in the diagnosis of hepatocellular carcinoma (HCC) by providing real-time continuous visualization of hepatic perfusion in focal liver lesions. To standardize and unify image acquisition and reporting in CEUS and to facilitate communication between clinicians and imaging physicians, the American College of Radiology (ACR) released the CEUS Liver Imaging Reporting and Data Reporting System (LI-RADS) in 2016 and revised it in 2017. Nowadays it has been widely used in most European and Asian countries and regions. This article reviews the application of CEUS LI-RADS.