| 摘要: |
| 目的：探讨超声造影与剪切波弹性成像（SWE）技术在慢性乙型肝炎（CHB）肝纤维化评估中的应用价值。方法：选取2015年1月~2018年12月我院收治的CHB患者120例，均行超声造影及SWE检查，获得肝动静脉渡越时间（HAVTT）值及肝脏弹性测值。结果：随着肝纤维化分期提高，HAVTT1、HAVTT2逐渐缩短，肝脏弹性测值逐渐增大；HAVTT1、HAVTT2及肝脏弹性测值在无纤维化组、纤维化组及肝硬化组之间两两比较均有统计学差异（P <0.05）。ROC曲线分析显示，HAVTT1、HAVTT2诊断肝纤维化及肝硬化的曲线下面积分别为0.870、0.851和0.889、0.856，肝脏弹性测值诊断肝纤维化及肝硬化的曲线下面积为分别为0.953、0.898；肝脏弹性测值的诊断效能明显优于HAVTT1及HAVTT2（P<0.05）。结论：SWE技术获得肝脏弹性值对乙肝纤维化及肝硬化的诊断优于超声造影。 |
| 关键词: 慢性乙型肝炎 肝纤维化 肝硬化 超声造影 剪切波弹性成像 |
| DOI： |
| 投稿时间：2019-06-04修订日期：2019-06-06 |
| 基金项目: |
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| Application of contrast-enhanced ultrasound and SWE in the evaluation of hepatitis B liver fibrosis |
| tangxiaoyan |
| () |
| Abstract: |
| Objective：To explore the application value of contrast-enhanced ultrasound and shear-wave elastography (SWE) in the evaluation of chronic hepatitis B (CHB) liver fibrosis. Methods：A total of 120 patients with CHB admitted to our hospital from January 2015 to December 2018 were selected, and they were given contrast-enhanced ultrasound and SWE, and the hepatic arteriovenous transit time (HAVTT) and liver elasticity measurement value were obtained. Results： With the increase of liver fibrosis stage, HAVTT1 and HAVTT2 were gradually shortened, and liver elasticity measurement value was gradually increased. There were statistically significant differences in the HAVTT1, HAVTT2 and liver elasticity measurement value between any two groups among non-fibrosis group, fibrosis group and cirrhosis group (P<0.05). ROC curve analysis showed that the values of area under the curve of HAVTT1 and HAVTT2 in the diagnosis of liver fibrosis and cirrhosis were 0.870 and 0.851 and 0.889 and 0.856 respectively, and the values of area under the curve of liver elasticity measurement value in the diagnosis of liver fibrosis and cirrhosis were 0.953 and 0.898 respectively. The diagnostic efficacy of liver elasticity measurement value was significantly better than that of HAVTT1 and HAVTT2 (P<0.05). Conclusion：SWE is superior to contrast-enhanced ultrasound in the diagnosis of liver fibrosis and cirrhosis. |
| Key words: Chronic hepatitis B Liver fibrosis Cirrhosis Contrast-enhanced ultrasound Shear -wave elastography |
