摘要: |
目的 应用高频超声血管内中膜分析技术(quality intima-media thickness,QIMT)和血管硬度定量分析技术QAS(quality arterial stiffness)研究糖尿病和肥胖对颈动脉血管结构和弹性功能的联合影响及其相关性。方法 将90名糖尿病患者和与之性别、体重相匹配的非糖尿病对照者90例,根据体重指数(BMI)分别分为三组。采用QIMT、QAS技术测量各组研究对象的颈动脉内-中膜厚度(IMT)、颈动脉僵硬度指数(β)、脉搏波传播速度(PWV)及顺应性系数(CC),并将各参数做相关性分析。结果 在同一BMI类别中与对照组相比,DM组的颈动脉IMT、PWV及β值均明显增高,顺应性CC明显降低,差异具有统计学意义(P<0.05)。随着BMI水平的增高,病例组和对照组的IMT、PWV、β均逐渐增高,而CC逐渐下降(P<0.05)。多变量分析显示,DM和肥胖均与颈动脉内中膜厚度和血管弹性功能的损害效应独立相关。然而,与DM危险因素比较,BMI类别增加对颈动脉血管结构和弹性功能的损害作用更大。结论 DM和肥胖均能独立引起颈动脉血管结构和弹性功能损害,DM患者合并肥胖对血管功能有叠加损害效应,可进一步加重DM颈部动脉粥样硬化程度,并且肥胖比DM对颈动脉血管结构与弹性功能的损害作用更大。 |
关键词: 肥胖 糖尿病 血管内中膜分析技术 血管僵硬度定量分析技术 颈动脉 |
DOI: |
投稿时间:2020-03-03修订日期:2020-03-25 |
基金项目: |
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Effects of diabetes and obesity on carotid intima thickness and vascular hardness |
sujin,zhu yongsheng,Luo Xiuxia,Ge Quanrong,Li Ping |
(Department of Ultrasonography, Southern Medical University Shenzhen Hospital, Shenzhen, China) |
Abstract: |
Objective To investigate the impact of diabetes mellitus (DM)and increasing body mass index (BMI) category on carotid vascular structure and elastic function assessed by the quality intima-media thickness (QIMT) and quality arterial stiffness (QAS) techniques of high-frequency ultrasound, and observe their correlation. Methods 90 diabetic patients and 90 non-diabetic sex and BMI matched control subjects were enrolled in this study. The two groups were then divided into three subgroups based on the BMI category. High frequency ultrasound QIMT and QAS technology were used to determine the intima-media thickness (IMT), stiffness index (β), pulse wave propagation velocity (PWV) and compliance coefficient (CC) of common carotid artery in all subjects. Also, the correlations between elastic parameters of common carotid artery parameters were analyzed. Results In the same BMI categories, the values of carotid IMT, PWV and β in DM patients were significantly higher than those in NON-DM subjects, while CC was lower than that in NON-DM patients (P<0.05). Also, carotid IMT, PWV and β in both DM and control group were increasing with BMI, and CC was decreasing with BMI. On multivariate linear regression analysis, both DM and obesity were independently associated with an additive detrimental effect on carotid intima thickness and vascular elasticity. Interestingly, obesity seems to be more associated with carotid dysfunction than DM.
Conclusion Both DM and increased BMI have additive adverse effects on carotid vascular structure and vascular elastic function. Furthermore, increasing BMI classification was associated with greater carotid dysfunction than DM. Future clinical studies on DM should simultaneously focus on the obesity. |
Key words: Obesity Diabetes Quality intima-media thickness Quality arterial stiffness Carotid artery |